反应详情

温度

110 °C

A mixture of 2-bromo-1-fluoro-4-nitrobenzene (15 g, 68 mmol), 2,4-difluorophenol (7.82 mL, 82 mmol), and cesium carbonate (26.7 g, 82 mmol) in dimethylsulfoxide (75 mL) was heated at 110° C. for 1 hour. The reaction mixture was cooled to ambient temperature and water (1000 mL) and saturated aqueous sodium chloride (1000 mL) were added. The mixture was extracted with ethyl acetate (3×200 mL). The combined organics were washed with saturated aqueous sodium chloride, dried (anhydrous magnesium sulfate), filtered, and concentrated under reduced pressure to provide 2-bromo-1-(2,4-difluorophenoxy)-4-nitrobenzene (22.5 g, quantitative).

1. temperatureThe reaction mixture was cooled to ambient temperature
2. extractionThe mixture was extracted with ethyl acetate (3×200 mL)
3. washThe combined organics were washed with saturated aqueous sodium chloride
4. dry with materialdried (anhydrous magnesium sulfate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure