Hydrogen chloride-ethyl acetate → HCID 118061391, compound

HRID 632809Notes

Reaction equation

HRID 632809 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][N:6]([C:9]2[C:13]([NH:14]C(=O)OC(C)(C)C)=[CH:12][N:11]([CH3:22])[N:10]=2)[C:5]1=[O:23].C(OC(=O)C)C.[ClH:30]>>[ClH:30].[NH2:14][C:13]1[C:9]([N:6]2[CH2:7][CH2:8][N:4]([CH2:3][CH2:2][OH:1])[C:5]2=[O:23])=[N:10][N:11]([CH3:22])[CH:12]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 131735463HCID 131735463, compound

Product 1

HCID 118061391HCID 118061391, compound

Procedure

To tert-butyl (3-(3-(2-hydroxyethyl)-2-oxoimidazolidin-1-yl)-1-methyl-1H-pyrazol-4-yl)carbamate (7.65 g) was added 4M hydrogen chloride ethyl acetate solution (76.5 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, to the residue was added methanol (30 mL), and the mixture was stirred for 10 min, and concentrated under reduced pressure to give the title compound (5.21 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, to the residue
  2. additionwas added methanol (30 mL)
  3. stirringthe mixture was stirred for 10 min
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-af37547b4c854ea2a2e9567650a62cbc
Source dataset
uspto-grants-2016_04
Patent number
US09321757B2

Reaction notes

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