Potassium Acetate → HCID 67975389, compound

Participants

Reaction Steps

Compound 39 (1000 mg, 2.22 mmol) was dissolved in 30 mL MeOH. Pd/C (10%) and KOAc (218 mg, 2.22 mol) were added. The mixture was placed under H2 and hydrogenated overnight. The mixture was filtrated over a plug of dicalite and evaporated. Compound 41 was purified by column chromatography on silicagel using CH2Cl2 to CH2Cl2/MeOH (NH3) 9-1 as the eluent. After evaporation 550 mg (59% yield) of 41 was obtained as a white solid with a purity of 99%. m/z=417 (M+H)+. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 0.93-1.05 (m, 2 H), 1.18 (s, 2 H), 1.91 (s, 2 H), 2.12-2.31 (m, 2 H), 2.91 (tt, J=6.93, 3.48 Hz, 1 H), 4.46 (t, J=7.80 Hz, 2 H), 5.42 (s, 2 H), 7.14 (d, J=5.27 Hz, 1 H), 7.25 (dd, J=8.28, 4.77 Hz, 1 H), 7.66 (dd, J=8.16, 1.38 Hz, 1 H), 8.36 (d, J=5.27 Hz, 1 H), 8.59 (dd, J=4.77, 1.51 Hz, 1 H), 8.80 (s, 1 H).

Provenance & Evidence