反应详情

1,1-dimethylethyl 7-(5-fluoro-2-{[(4-methyl-2-pyridinyl)methyl]oxy}phenyl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate, (0.304 g) was dissolved in a minimum amount of dioxane. The solution was cooled in ice and to this was added a solution of HCl in dioxane (2 ml). This was stirred until the reaction had gone to completion by tlc. The reaction mixture was concentrated in vacuo. The product salt was dissolved in water and backwashed with ethyl acetate. The aqueous was neutralised with aqueous sodium hydroxide (1M). This was extracted with ethyl acetate. The organics were dried over sodium sulphate and concentrated to give the title compound, 100 mg.

1. temperatureThe solution was cooled in ice
2. concentrationThe reaction mixture was concentrated in vacuo
3. dissolutionThe product salt was dissolved in water
4. extractionThis was extracted with ethyl acetate
5. dry with materialThe organics were dried over sodium sulphate
6. concentrationconcentrated