HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → 5-Iodo-4-(trifluoromethyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 2-Amino-4-(trifluoromethyl)pyridine | HCID 2778315 | — |
| Product | 5-Iodo-4-(trifluoromethyl)pyridin-2-amine | HCID 58073054 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP1 starting from 20.0 g (123 mmol) 4-trifluoromethyl-pyridin-2-ylamine and 27.8 g (123 mmol) NIS. Yield after precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography in silica gel: 20.3 g (57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321771B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-2f712e3831504847a24488461390c8ab |
| Source note | uspto-grants-2016_04 |