HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Pyridinamine, 5-ethynyl-4-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 58072883 | HCID 58072883 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Pyridinamine, 5-ethynyl-4-methyl- | HCID 9964100 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP3 starting from 1.8 g (8.8 mmol) 4-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 609 mg (4.4 mmol) K2CO3 in 315 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 1.0 g (86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321771B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-aa35505cd9ee424ba8f0803bc1edcd7e |
| Source note | uspto-grants-2016_04 |