反应详情

To a solution of 1,1-dimethylethyl 7-(5-acetyl-2-{[(4-ethyl-2-pyridinyl)methyl]oxy}phenyl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate, (0.217 g) in DCM (3 ml) was added TFA (0.4 ml). This was stirred at room temperature. After completion of reaction by tlc, the reaction mixture was concentrated in vacuo and purified by preparative hplc. Product fractions were concentrated in vacuo and the product obtained was partitioned between DCM and aqueous sodium bicarbonate. The organics were dried over sodium sulphate and concentrated in vacuo to yield the title compound, 0.035 g

1. customAfter completion of reaction by tlc
2. concentrationthe reaction mixture was concentrated in vacuo
3. custompurified by preparative hplc
4. concentrationProduct fractions were concentrated in vacuo
5. customthe product obtained
6. customwas partitioned between DCM and aqueous sodium bicarbonate
7. dry with materialThe organics were dried over sodium sulphate
8. concentrationconcentrated in vacuo