HRID63293

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID87836

1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene

C11H15Br

HCID3411566

5-Bromoindoline

C8H8BrN

结构：CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1

HCID16217654

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

C14H23BN2O4

结构：CC(C)c1ccc(CN2CCc3cc(-c4cn[nH]c4)ccc32)cc1

HCID90011062

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1ccc(CN2CCc3cc(-c4cn[nH]c4)ccc32)cc1

HCID90068395

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

1-(4-Isopropylbenzyl)-5-(1H-pyrazol-4-yl)indoline, 50 can be prepared by alkylation of 5-bromoindoline, 22 with 1-(bromomethyl)-4-(tert-butyl)benzene using the conditions described in Example 7, part 1 followed by palladium catalyzed coupling of the alkylation product with tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate, 10 followed by hydrolysis using the reaction conditions described in Example 8.

WORKUP

后处理

customfollowed by hydrolysis
customthe reaction conditions