1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 178500675, compound

Participants

Reaction Steps

Trans-{4-[4-(3-aminopropionylamino)phenyl]cyclohexyl}acetic acid methyl ester HCl salt (50 mg, 0.14 mmol), EDCI (67.5 mg, 0.35 mmol), 2-(2-fluorophenyl)-5-trifluoromethyloxazole-4-carboxylic acid (46.5 mg, 0.17 mmol), HOBt (28.6 mg, 0.2 mmol) and ethyldiisopropylamine (63.9 mg, 0.5 mmol) dissolved in dichloromethane solvent (10 mL) were stirred for 24 hours. The reaction mixture was diluted with aqueous NaHCO3 and extracted with dichloromethane. The extract was washed with brine and dried with anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by a silica gel column chromatography to obtain trans-{4-[4-(3-{[2-(2-fluorophenyl)-5-trifluoromethyloxazole-4-carbonyl]amino}propionylamino)phenyl]cyclohexyl}acetic acid methyl ester (73 mg, 90%) as a white solid.

Provenance & Evidence