1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 178500672, compound

Participants

Reaction Steps

Trans-{4-[4-(3-aminopropionylamino)phenyl]cyclohexyl}acetic acid methyl ester HCl salt (300 mg, 0.846 mmol), EDCI (405.23 mg, 2.114 mmol), 5-trifluoromethyl-2-(2-trifluoromethylphenyl)oxazole-4-carboxylic acid (288.68 mg, 0.888 mmol), HOBt (171.39 mg, 1.268 mmol) and ethyldiisopropylamine (383.39 mg, 2.959 mmol) were put into dichloromethane solvent (10 mL) and stirred at room temperature for 24 hours. After the reaction, aqueous NaHCO3 was added thereto, and extracted with dichloromethane. The organic layer was washed with brine, then the product was dried with anhydrous sodium sulfate, and the solvent was removed. Column chromatography was conducted on the crude material to obtain trans-{4-[4-(3-{[5-trifluoromethyl-2-(2-trifluoromethylphenyl)oxazole-4-carbonyl]amino}propionylamino)phenyl]cyclohexyl}acetic acid methyl ester (461 mg, 87%).

Provenance & Evidence