HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Acetylthiophene-2-carboxylic acid → 5-Acetyl-N-(4-chloro-3-iodophenyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Acetylthiophene-2-carboxylic acid | HCID 3742727 | — |
| Reactant | 4-Chloro-3-iodoaniline | HCID 21874954 | — |
| Product | 5-Acetyl-N-(4-chloro-3-iodophenyl)thiophene-2-carboxamide | HCID 66877896 | — |
Reaction Steps
4-Chloro-3-iodoaniline (2.5 g, 9.88 mmol) was used in Procedure E with 5-acetylthiophene-2-carboxylic acid (1.85 g, 10.8 mmol) at 23° C. for 2 hours. The crude material was purified by silica gel chromatography (20-100% ethyl acetate/hexanes) to yield 5-Acetyl-N-(4-chloro-3-iodophenyl)thiophene-2-carboxamide as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321761B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-6fa9076ad39443318665fdeef22e9ee6 |
| Source note | uspto-grants-2016_04 |