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HRID 633034作成日：2026年10月25日

2-Bromo-4-ethylpyridine → N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

https://huagongshe.com/reaction/633034

反応式

関与物質

役割名称HCID仕込み量
反応物2-Bromo-4-ethylpyridineHCID 4114248—
反応物N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamideHCID 66896658—
生成物N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamideHCID 58614779—

反応手順

N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (˜1 mmol) was used in Procedure A with 4-ethyl-2-bromopyridine (1 mmol). Purified by silica gel chromatography (0-60% ethyl acetate/hexanes) to yield N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a tan solid: MS (Q1) 419 (M)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09321761B2
出典データセットuspto-grants-2016_04
ORD IDord-dfc9f504237e46a2b3906327e634e5ff
出典メモuspto-grants-2016_04