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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633041Generated: October 26, 2026

2-Pyridinemethanamine → N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(pyridin-2-ylmethyl)terephthalamide

https://huagongshe.com/reaction/633041

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PyridinemethanamineHCID 19509—
Reactant4-(4-Chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acidHCID 66877887—
ProductN1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(pyridin-2-ylmethyl)terephthalamideHCID 58614724—

Reaction Steps

50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2-(aminomethyl)pyridine via Procedure G. The product was purified on reverse phase HPLC to yield N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(pyridin-2-ylmethyl)terephthalamide. MS (Q1) 443 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-cdf0b3403c3a447c9b7e2d72cf8a5a66
Source noteuspto-grants-2016_04