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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633063Generated: October 30, 2026

1,4,5,6-Tetrahydropyrimidine → 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1,4,5,6-tetrahydropyrimidine-1-carbonyl)benzamide

https://huagongshe.com/reaction/633063

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4,5,6-TetrahydropyrimidineHCID 137105—
Reactant3-Chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acidHCID 66878605—
Product2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1,4,5,6-tetrahydropyrimidine-1-carbonyl)benzamideHCID 58614889—

Reaction Steps

50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1,4,5,6-tetrahydropyrimidine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1,4,5,6-tetrahydropyrimidine-1-carbonyl)benzamide. MS (Q1) 454 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-ac025372f9944f8399a2134d851db2fc
Source noteuspto-grants-2016_04