HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanamine, 1-methoxy-, (2S)- → (S)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(1-methoxypropan-2-yl)terephthalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanamine, 1-methoxy-, (2S)- | HCID 7021536 | — |
| Reactant | 3-Chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid | HCID 66878605 | — |
| Product | (S)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(1-methoxypropan-2-yl)terephthalamide | HCID 58614772 | — |
Reaction Steps
75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (S)-1-methoxy-2-propylamine via Procedure G. The product was purified on reverse phase HPLC to yield (S)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(1-methoxypropan-2-yl)terephthalamide. MS (Q1) 459 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321761B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-032f94ac13ba4ea7a185f9e7b003a141 |
| Source note | uspto-grants-2016_04 |