Aluminium lithium hydride → HCID 86694595, compound

Participants

Reaction Steps

LiAlH4 reduction of (E)-3-(5-(2-cyclohexylvinyl)pyridin-3-yl)-3-hydroxypropanenitrile following the method used in Example 3 gave after flash chromatography purification (10%-30% 7N NH3/MeOH—CH2Cl2 gradient) Example 10 as a light yellow oil. Yield (0.5 g, 59%); 1H NMR (400 MHz, CD3OD) δ 8.37 (d, J=2.0 Hz, 1H), 8.33 (d, J=1.5 Hz, 1H), 7.85 (t, J=2.0 Hz, 1H), 6.40-6.38 (m, 2H), 4.84-4.76 (m, 1H), 2.86-2.78 (m, 2H), 2.24-2.08 (m, 1H), 1.98-1.66 (m, 7H), 1.44-1.28 (m, 5H); RP-HPLC tR=6.23 min; ESI-MS m/z 261.2 [M+H]+.

Provenance & Evidence