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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633109Generated: November 1, 2026

4-Chloro-3-(pyridin-2-yl)aniline → HCID 58614742, compound

https://huagongshe.com/reaction/633109

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
ReactantHCID 43427173HCID 43427173—
ProductHCID 58614742HCID 58614742—

Reaction Steps

250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to isopropylamine via Procedure G. Crude methyl 6-(isopropylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 227 mg of 6-(isopropylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(isopropylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N5-(4-chloro-3-(pyridin-2-yl)phenyl)-N2-isopropylpyridine-2,5-dicarboxamide. MS (Q1) 395.1 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-f348a78652534cc5bca29195a5462967
Source noteuspto-grants-2016_04