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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633111Generated: October 30, 2026

HCID 10632805, compound → HCID 58614755, compound

https://huagongshe.com/reaction/633111

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 10632805HCID 10632805—
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
ProductHCID 58614755HCID 58614755—

Reaction Steps

250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to tert-butylamine via Procedure G. Crude methyl 6-(tert-butylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 250 mg of 6-(tert-butylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(tert-butylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N2-tert-butyl-N5-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide. MS (Q1) 409 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-6d02d1a7eb8a49e3be26b92f369cffeb
Source noteuspto-grants-2016_04