Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633113Generated: October 29, 2026

4-Chloro-3-(pyridin-2-yl)aniline → HCID 58614746, compound

https://huagongshe.com/reaction/633113

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
ReactantHCID 43427235HCID 43427235—
ProductHCID 58614746HCID 58614746—

Reaction Steps

250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to pyridin-2-ylmethanamine via Procedure G. Crude methyl 6-(pyridin-2-ylmethylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 250 mg of 6-(pyridin-2-ylmethylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(pyridin-2-ylmethylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N5-(4-chloro-3-(pyridin-2-yl)phenyl)-N2-(pyridin-2-ylmethyl)pyridine-2,5-dicarboxamide. MS (Q1) 444.1 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-14a396dfe76c48babcb78eb3c3fbe3c6
Source noteuspto-grants-2016_04