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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633114Generated: October 31, 2026

Benzylamine → HCID 43427193, compound

https://huagongshe.com/reaction/633114

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
Reactant5-(Methoxycarbonyl)pyridine-2-carboxylic acidHCID 314992—
ReactantHCID 14210548HCID 14210548—
ProductHCID 43427193HCID 43427193—

Reaction Steps

250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to benzylamine via Procedure G. Crude methyl 6-(benzylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 300 mg of 6-(benzylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(benzylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N2-benzyl-N5-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-b15e1bf80755460ab436eea9ac3eca7f
Source noteuspto-grants-2016_04