Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633115Generated: October 30, 2026

4-Chloro-3-(pyridin-2-yl)aniline → HCID 58614825, compound

https://huagongshe.com/reaction/633115

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
ReactantHCID 43427193HCID 43427193—
ProductHCID 58614825HCID 58614825—

Reaction Steps

250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to benzylamine via Procedure G. Crude methyl 6-(benzylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 300 mg of 6-(benzylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(benzylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N2-benzyl-N5-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-68ea24e3cd7248fbaa48f749e1c5f89d
Source noteuspto-grants-2016_04