HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-3-pyridinylamine → HCID 43427281, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-3-pyridinylamine | HCID 81121 | — |
| Reactant | 5-(Methoxycarbonyl)pyridine-2-carboxylic acid | HCID 314992 | — |
| Reactant | HCID 31941802 | HCID 31941802 | — |
| Product | HCID 43427281 | HCID 43427281 | — |
Reaction Steps
250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to 6-methoxypyridin-3-amine via Procedure G. Crude methyl 6-(6-methoxypyridin-3-ylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 196 mg of 6-(6-methoxypyridin-3-ylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(6-methoxypyridin-3-ylcarbamoyl)nicotinic acid via Procedure G. The crude product was recrystallized to yield pure N5-(4-chloro-3-(pyridin-2-yl)phenyl)-N2-(6-methoxypyridin-3-yl)pyridine-2,5-dicarboxamide. MS (Q1) 460 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321761B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-c5af99f5089c4cdc959a006329c6a90d |
| Source note | uspto-grants-2016_04 |