HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)benzoic acid → HCID 58614895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)benzoic acid | HCID 22599 | — |
| Reactant | Captamine Hydrochloride | HCID 25798 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Reactant | 4-Chloro-3-(pyridin-2-yl)aniline | HCID 40151925 | — |
| Reactant | HCID 66877754 | HCID 66877754 | — |
| Reactant | 4-(Bromomethyl)-N-[4-chloro-3-(2-pyridinyl)phenyl]benzamide | HCID 66878170 | — |
| Product | HCID 58614895 | HCID 58614895 | — |
Reaction Steps
500 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(bromomethyl)benzoic acid via Procedure E. 170 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was reacted with 2-(dimethylamino)ethanethiol hydrochloride via Procedure Q. 140 mg of crude N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2-(dimethylamino)ethylthio)methyl)benzamide was reacted with oxone via Procedure R. The crude product was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2-(dimethylamino)ethylsulfonyl)methyl)benzamide. MS (Q1) 458.3 (M)4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321761B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-1dd4718f895e4d078d1d63c1ef3481f6 |
| Source note | uspto-grants-2016_04 |