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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633185Generated: October 30, 2026

4-(Chlorosulfonyl)benzoic acid → HCID 58614909, compound

https://huagongshe.com/reaction/633185

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chlorosulfonyl)benzoic acidHCID 82385—
Reactant1-AcetylpiperazineHCID 83795—
ReactantHCID 7730578HCID 7730578—
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
ProductHCID 58614909HCID 58614909—

Reaction Steps

1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 646 μL of 1-(piperazin-1-yl)ethanone via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-(4-acetylpiperazin-1-ylsulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield 4-(4-acetylpiperazin-1-ylsulfonyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 499.4 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-7b62135b01ab4688bdf0cbcacc67aaca
Source noteuspto-grants-2016_04