Acetonitrile → HCID 86694611, compound

HRID 63319Notes

Reaction equation

HRID 63319 reaction equation
[CH:1]1(/[CH:7]=[CH:8]/[C:9]2[S:13][CH:12]=[C:11]([CH:14]=[O:15])[CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:16][C:17]#[N:18]>>[CH:1]1(/[CH:7]=[CH:8]/[C:9]2[S:13][CH:12]=[C:11]([CH:14]([OH:15])[CH2:16][C:17]#[N:18])[CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 86694612HCID 86694612, compound

Product 1

HCID 86694611HCID 86694611, compound

Procedure

Addition of CH3CN to (E)-5-(2-cyclohexylvinyl)thiophene-3-carbaldehyde following the method used in Example 3 gave (E)-3-(5-(2-cyclohexylvinyl)thiophen-3-yl)-3-hydroxypropanenitrile as a yellow oil which was used in the next step without further purification. Yield (0.47 g, quant.).

Sources & evidence

ORD record
ord-ba286324ec954dfc9d3c431a88e826e1
Source dataset
uspto-grants-2016_09
Patent number
US09447078B2

Reaction notes

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