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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633261Generated: October 29, 2026

4-Chloro-3-(pyridin-2-yl)aniline → HCID 58614721, compound

https://huagongshe.com/reaction/633261

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
Reactant6-(Methylsulfonyl)nicotinic AcidHCID 53429616—
ProductHCID 58614721HCID 58614721—

Reaction Steps

1 g of methyl 6-chloronicotinate was reacted via Procedure O to yield methyl 6-(methylsulfonyl)nicotinate. 1 g of methyl 6-(methylsulfonyl)nicotinate was hydrolyzed via Procedure M to give 6-(methylsulfonyl)nicotinic acid. 100 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(methylsulfonyl)nicotinic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonyl)nicotinamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321761B2
Source datasetuspto-grants-2016_04
ORD IDord-4c23472489ed40b3b75997cc9a56d9e8
Source noteuspto-grants-2016_04