Acetonitrile → HCID 86694623, compound

HRID 63327Notes

Reaction equation

HRID 63327 reaction equation
[CH:1]1([CH2:7][S:8][C:9]2[N:14]=[C:13]([C:15]([O:17]C)=O)[CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]#[N:21]>>[CH:1]1([CH2:7][S:8][C:9]2[N:14]=[C:13]([C:15](=[O:17])[CH2:19][C:20]#[N:21])[CH:12]=[CH:11][CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 86694624HCID 86694624, compound

Product 1

HCID 86694623HCID 86694623, compound

Procedure

Addition of CH3CN to methyl 6-((cyclohexylmethyl)thio)picolinate following the method used in Example 6 gave 3-(6-((cyclohexylmethyl)thio)pyridin-2-yl)-3-oxopropanenitrile as a yellow oil which was used in the next step without further purification. Yield (0.63 g, quant.).

Sources & evidence

ORD record
ord-afc9e40261744a3f9eb708130c5566ba
Source dataset
uspto-grants-2016_09
Patent number
US09447078B2

Reaction notes

Loading…