Ammonia methanol dichloromethane → HCID 86694625, compound

Participants

Reaction Steps

Reduction of (R)-3-(6-((cyclohexylmethyl)thio)pyridin-2-yl)-3-hydroxypropanenitrile following the method described in Example 6 gave after flash chromatography purification (15%-20% 7N NH3/MeOH—CH2Cl2 gradient) Example 25 as a colorless oil. Yield (0.3 g, 43%); 1H NMR (400 MHz, CD3OD) δ 7.56 (t, J=7.6 Hz, 1H), 7.17 (d, J=7.6 Hz, 1H), 7.09 (d, J=8.0 Hz, 1H), 4.75-4.72 (m, 1H), 3.04 (d, J=7.2 Hz, 2H), 2.80 (t, J=7.6 Hz, 2H), 2.03-1.98 (m, 1H), 1.94-1.54 (m, 7H), 1.30-0.99 (m, 5H); RP-HPLC tR=9.63 min; ESI-MS m/z 281.2 [M+H]+.

Provenance & Evidence