HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633290Generated: October 30, 2026
1H-1,2,4-Triazole → HCID 58614635, compound
https://huagongshe.com/reaction/633290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide | HCID 58614798 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58614635 | HCID 58614635 | — |
Reaction Steps
A mixture of 41 mg of 1,2,4-triazol and 14 mg of sodium hydride in 2 mL of DMF was stirred for 10 min. 70 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide was added. The reaction was heated to 140° C. for 6 h. The reaction mixture was quenched with MeOH and evaporated. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(1H-1,2,4-triazol-1-yl)nicotinamide. MS (Q1) 391.4 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09321761B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-25b5d9599dda4208b2eecbf6d0ca8be7 |
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| Source note | uspto-grants-2016_04 |
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