Acetonitrile → HCID 86694643, compound

HRID 63338Notes

Reaction equation

HRID 63338 reaction equation
[CH:1]1([CH2:6][O:7][C:8]2[N:13]=[C:12]([C:14]([O:16]C)=O)[CH:11]=[CH:10][CH:9]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:18][C:19]#[N:20]>>[CH:1]1([CH2:6][O:7][C:8]2[N:13]=[C:12]([C:14](=[O:16])[CH2:18][C:19]#[N:20])[CH:11]=[CH:10][CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 86694644HCID 86694644, compound

Product 1

HCID 86694643HCID 86694643, compound

Procedure

CH3CN addition to methyl 6-(cyclopentylmethoxy)picolinate following the method described in Example 6 gave 3-(6-(cyclopentylmethoxy)pyridin-2-yl)-3-oxopropanenitrile as a yellow oil which was used in the next step without further purification. Yield (1.22 g, quant.).

Sources & evidence

ORD record
ord-84b4c55e43d840f8bde3b3f88936b11e
Source dataset
uspto-grants-2016_09
Patent number
US09447078B2

Reaction notes

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