Aluminium lithium hydride → HCID 86694649, compound

Participants

Reaction Steps

LiAlH4 reduction of (R)-3-(6-(cycloheptyloxy)pyridin-2-yl)-3-hydroxypropanenitrile following the method described in Example 1 gave after flash chromatography purification (20%-30% 7N NH3/MeOH—CH2Cl2 gradient) Example 34 as a colorless oil. Yield (0.19 g, 14%); 1H NMR (400 MHz, DMSO-d6) δ 7.58 (t, J=8.0 Hz, 1H), 6.97 (d, J=7.2 Hz, 1H), 6.51 (d, J=8.0 Hz, 1H), 5.16-5.08 (m, 1H), 4.56-4.48 (m, 1H), 2.72-2.56 (m, 2H), 1.98-1.36 (m, 14H); RP-HPLC tR=7.98 min; ESI-MS m/z 265.2 [M+H]+.

Provenance & Evidence