HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Difluoro-4-nitrobenzene → HCID 58377132, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Reactant | 2-(tert-Butyl(dimethyl)silyl)oxyethanol | HCID 11137665 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58377132 | HCID 58377132 | 102.1% |
Reaction Steps
The same procedure detailed below for Compound 133 was used, but using 3,4-difluoronitrobenzene (225 mg, 1.4 mmol), potassium tert-butoxide (354 mg, 3.2 mmol) and 2-((tert-butyldimethylsilyl)oxy)ethan-1-ol (506 mg, 2.9 mmol) in THF (3 mL) to give the product (451 mg) after workup (yield assumed quantitative). The product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321763B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-8e84b5f8cbe34142baeebc868d6f800e |
| Source note | uspto-grants-2016_04 |