Acetonitrile → HCID 86694653, compound

HRID 63344Notes

Reaction equation

HRID 63344 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][O:18][C:19]2[N:24]=[C:23]([C:25]([O-:27])=O)[CH:22]=[CH:21][CH:20]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:28][C:29]#[N:30]>>[C:29]([CH2:28][C:25]([C:23]1[N:24]=[C:19]([O:18][CH2:17][CH:14]2[CH2:13][CH2:12][N:11]([C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[O:10])[CH2:16][CH2:15]2)[CH:20]=[CH:21][CH:22]=1)=[O:27])#[N:30]

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 86694654HCID 86694654, compound

Product 1

HCID 86694653HCID 86694653, compound

Procedure

CH3CN addition to 6-((1-((benzyloxy)carbonyl)piperidin-4-yl)methoxy)picolinate following the method described in Example 6 gave benzyl 4-(((6-(2-cyanoacetyl)pyridin-2-yl)oxy)methyl)piperidine-1-carboxylate in which was used in the next step without further purification. Yield (1.53 g, quant).

Sources & evidence

ORD record
ord-2b4ae18815464377bca86c30f7cea6fb
Source dataset
uspto-grants-2016_09
Patent number
US09447078B2

Reaction notes

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