2,2,4-trimethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one → 6-amino-2,2,4-trimethyl-2H-1,4-benzoxazine-3(4H)-one

Participants

Reaction Steps

A mixture of 2,2,4-trimethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one (290 mg, 1.23 mmol, 1 equiv.) in 10 mL of MeOH in the presence of 29 mg of Pd/C was hydrogenated at room temperature for 3 h. The reaction mixture was then filtered through a pad of celite and the filtrate was concentrated to give 240 mg (Yield=95%) of product as a pale brown solid which was used in the next step without further purification.

Provenance & Evidence