反应详情

SOCl2 (1.1 mL, 14.62 mmol, 1 equiv.) was added to a solution of 4-amino-2-trifluoromethylbenzoic acid (3 g, 14.62 mmol, 1 equiv.) in 40 mL of MeOH and the reaction mixture was refluxed overnight. Solvent was removed in vacuo and the residue was taken into EtOAc and washed with sat. NaHCO3 (×2), brine and dried over MgSO4, and concentrated to give 2.06 g (Yield=64%) of product as a clear oil.

1. temperaturethe reaction mixture was refluxed overnight
2. customSolvent was removed in vacuo
3. washwashed with sat. NaHCO3 (×2), brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated