Aluminium lithium hydride → HCID 86694665, compound

Participants

Reaction Steps

LiAlH4 reduction of tert-butyl (3-hydroxy-3-(6-((2-propylpentyl)oxy)pyridin-2-yl)propyl)carbamate following the method described in Example 1 gave after flash chromatography purification (30%-40% 7N NH3/MeOH—CH2Cl2 gradient) Example 43 as a colorless oil; Yield (0.04 g, 62%); 1H NMR (400 MHz, DMSO-d6) δ 7.63 (t, J=8.4 Hz, 1H), 7.03 (d, J=8.0 Hz, 1H), 6.62 (d, J=8.0 Hz, 1H), 4.69-4.66 (m, 1H), 4.18-4.16 (m, 2H), 2.76-2.72 (m, 2H), 2.40 (s, 3H), 2.10-1.68 (m, 3H), 1.46-1.26 (m, 8H), 0.96-0.88 (m, 6H); RP-HPLC tR=10.66 min; ESI-MS m/z 295.3 [M+H]+.

Provenance & Evidence