Hydrochloric Acid → HCID 90415587, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 11E (0.120 g, 0.252 mmol) and 4 M hydrogen chloride in dioxane (10 mL, 40.0 mmol) were combined and heated at 70° C. for 24 hours, cooled and concentrated. The residue was purified by reverse phase HPLC (C18, CH3CN/water (0.1% TFA), 10-100%) to afford the title compound (0.080 g, 68%). 1H NMR (300 MHz, DMSO-d6) δ ppm 10.95 (d, J=5.43 Hz, 1H) 9.57 (s, 1H) 7.41-7.55 (m, 3H) 7.23-7.34 (m, 1H) 7.05-7.15 (m, 1H) 6.86-6.93 (m, 1H) 6.79 (d, J=11.19 Hz, 1H) 6.51 (d, J=5.76 Hz, 1H) 4.09 (s, 3H) 3.03 (s, 3H). MS (ESI+) m/z 464 (M+H)+.

Provenance & Evidence