Hydrochloric Acid → HCID 86287692, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 12A (0.066 g, 0.138 mmol) and 4 M hydrogen chloride in dioxane (10 mL, 40.0 mmol) were combined and heated at 70° C. for 24 hours, cooled and concentrated. The residue was purified by reverse phase HPLC (C18, CH3CN/water (0.1% TFA), 10-100%) to afford the title compound (0.022 g, 34%). 1H NMR (300 MHz, DMSO-d6) δ ppm 11.00 (d, J=5.09 Hz, 1H) 9.53 (s, 1H) 7.47-7.59 (m, 3H) 7.30-7.41 (m, 1H) 7.11-7.20 (m, 1H) 6.90-6.96 (m, 1H) 6.78 (d, J=10.85 Hz, 1H) 6.49 (d, J=7.12 Hz, 1H) 4.11 (s, 3H) 3.05 (s, 3H). MS (ESI+) m/z 464 (M+H)+.

Provenance & Evidence