Triethylamine → HCID 90416610, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Example 16D (0.03 g, 0.081 mmol), methanesulfonyl chloride (0.028 g, 0.243 mmol), and triethylamine (0.049 g, 0.486 mmol) in dichloromethane (3 mL) was stirred at ambient temperature for 2 hours. The solvent was removed, and the residue was treated with sodium hydroxide (0.656 mL, 1.31 mmol) and dioxane (3 mL). The reaction mixture was heated at 80° C. for 3 hours. After cooling, the reaction mixture was partitioned between water and ethyl acetate. The aqueous layer was extracted three times with ethyl acetate. The combined organic layers were washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered, and concentrated to give the title compound.

Provenance & Evidence