Ethyl Acetate → HCID 86721059, compound

Participants

Reaction Steps

A solution of 2,4-difluorophenol (5.39 g, 41.4 mmol) in dimethylformamide (34.5 mL) at 10° C. under nitrogen was treated portionwise with sodium hydride (1.657 g, 41.4 mmol), stirred for 15 minutes and treated portionwise with 4-fluoro-3-nitrobenzenesulfonamide (2.28 g, 10.36 mmol). The solution was stirred at ambient temperature for 1.5 hours, diluted into ethyl acetate and carefully quenched with 0.5 M HCl to a constant pH of 6. The organic layer was washed with saturated aqueous sodium chloride, dried (MgSO4), filtered, and concentrated. The residue was triturated in 3:1 hexane/ethyl acetate to afford the title compound (3.24 g, 95%).

Provenance & Evidence