Hydrochloric Acid → HCID 86287895, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 51D (0.116 g, 0.26 mmol) and 4 M hydrogen chloride (5 mL, 20.0 mmol) in dioxane were combined and heated at 70° C. for 24 hours, cooled and concentrated. Purification by reverse phase chromatography (C18, CH3CN/water (0.1% TFA), 10-100%) afforded the title compound (0.051 g, 45%). 1H NMR (300 MHz, DMSO-d6) δ ppm 10.99 (d, J=5.09 Hz, 1H) 7.96 (d, J=2.37 Hz, 1H) 7.66 (dd, J=8.82, 2.37 Hz, 1H) 7.64 (s, 1H) 7.46-7.57 (m, 1H) 7.35-7.43 (m, 1H) 7.33 (s, 2H) 7.12-7.21 (m, 1H) 6.94 (d, J=6.78 Hz, 1H) 6.90 (d, J=8.48 Hz, 1H) 6.55 (d, J=6.10 Hz, 1H) 4.12 (s, 3H). MS (ESI+) m/z 432 (M+H)+.

Provenance & Evidence