HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 633554Generated: October 29, 2026
Hydrochloric Acid → 5-Bromo-6-(2,4-difluorophenoxy)nicotinic acid
https://huagongshe.com/reaction/633554
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,4-Difluorophenol | HCID 123051 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-6-(2,4-difluorophenoxy)nicotinic acid | HCID 86721074 | 67.7% |
Reaction Steps
5-Bromo-6-chloronicotinic acid (3.00 g, 12.7 mmol), 2,4-difluorophenol (3.30 g, 25.4 mmol) and cesium carbonate (16.5 g, 50.8 mmol) were combined in DMSO (25.4 mL), heated at 100° C. for 6 hours, cooled, diluted with 150 mL of iced water and the pH was adjusted to pH 3 with 12M HCl. The resulting solid was collected by filtration, washed with cold water and dried to constant mass to afford the title compound (2.84 g, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09321764B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-28eff1edead04f21a987404d7b228152 |
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| Source note | uspto-grants-2016_04 |
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