反应详情

A solution of the product from Example 60D (0.66 g, 1.906 mmol) at 0° C. in methanol (7.33 mL) was treated with a solution of Oxone (2.461 g, 4.00 mmol) in water (7.33 mL), stirred at ambient temperature for two hours and partitioned between ethyl acetate and water. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous Na2SO4), filtered, and concentrated. Purification by chromatography (silica gel, 0-5% methanol in dichloromethane) afforded the title compound (0.433 g, 60%).

1. custompartitioned between ethyl acetate and water
2. washThe organic layer was washed with saturated aqueous sodium chloride
3. dry with materialdried (anhydrous Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customPurification by chromatography (silica gel, 0-5% methanol in dichloromethane)