HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanecarbaldehyde → N-(cyclopentylmethyl)-2-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-4-(methylsulfonyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanecarbaldehyde | HCID 70106 | — |
| Reactant | 2-(7-Methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-4-(methylsulfonyl)benzenamine | HCID 90387682 | — |
| Solvent | Dichloroethane acetic acid | HCID 18768099 | — |
| Product | N-(cyclopentylmethyl)-2-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-4-(methylsulfonyl)aniline | HCID 90417402 | 31% |
Reaction Steps
The product from Example 44A (55 mg, 0.166 mmol) and cyclopentanecarbaldehyde (58.64 mg, 0.597 mmol) in dichloroethane/acetic acid (1:1, 1 mL) was heated in a sealed tube at 60° C. for 24 hours, cooled, and concentrated. Purification by reverse phase HPLC (C18, CH3CN/water (0.1% TFA), 10-100%) afforded the title compound (0.021 g, 31%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321764B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3a2bfdcd3b7144f98e50d2836b0636cb |
| Source note | uspto-grants-2016_04 |