Hydrochloric Acid → HCID 90416369, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 91E (0.064 g, 0.119 mmol) and 4 M hydrogen chloride in dioxane (2 mL, 8.00 mmol) were combined and heated at 70° C. for 2 hours, cooled and concentrated. Purification by trituration (1:1 dichloromethane/heptane) afforded the title compound (0.042 g, 74%). 1H NMR (400 MHz, DMSO-d6) δ ppm 11.91 (s, 1H) 7.60 (s, 1H) 7.57 (d, J=2.03 Hz, 1H) 7.43-7.52 (m, 1H) 7.19-7.30 (m, 2H) 7.05-7.15 (m, 1H) 6.82 (d, J=8.14 Hz, 1H) 6.68 (s, 1H) 4.53 (s, 2H) 4.07 (s, 3H) 2.94 (s, 3H). MS (ESI+) m/z 479 (M+H)+.

Provenance & Evidence