Tributylvinyltin → HCID 90416820, compound

Participants

Reaction Conditions

Reaction Steps

Tributyl(vinyl)tin (0.053 g, 0.167 mmol), the product from Example 91E (0.075 g, 0.140 mmol) and Pd(PPh3)2Cl2 (9.80 mg, 0.014 mmol) were combined in dioxane (1.163 mL) and sparged with argon for 15 minutes. The mixture was stirred for 2 hours at 100° C., cooled and partitioned between ethyl acetate and water. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous Na2SO4), treated with 3-mercaptopropyl functionalized silica gel, filtered, and concentrated. Purification by chromatography (silica gel, 0-40% ethyl acetate in heptanes) afforded the title compound (0.041 g, 61%).

Provenance & Evidence