Hydrochloric Acid → HCID 86288110, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 92B (0.04 g, 0.082 mmol) and 4M hydrogen chloride in dioxane (5 mL, 20.00 mmol) were combined, heated at 70° C. for 3 hours, cooled and concentrated. Purification by chromatography (silica gel, 0-4% methanol in dichloromethane) afforded the title compound (0.035 g, 90%). 1H NMR (300 MHz, DMSO-d6) δ ppm 10.87 (s, 1H) 7.58 (d, J=2.03 Hz, 1H) 7.49 (s, 1H) 7.41-7.52 (m, 1H) 7.17-7.28 (m, 2H) 7.05-7.14 (m, 1H) 6.82 (d, J=8.14 Hz, 1H) 6.38 (s, 1H) 4.51 (s, 2H) 4.07 (s, 3H) 2.94 (s, 3H) 2.43 (q, J=7.63 Hz, 2H) 1.14 (t, J=7.46 Hz, 3H). MS (ESI+) m/z 473 (M+H)+.

Provenance & Evidence