Hydrochloric Acid → HCID 86288167, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 93A (0.1 g, 0.132 mmol) and 4 M hydrogen chloride in dioxane (5 mL, 20.00 mmol) were combined and heated at 70° C. for 4 hours, cooled and concentrated. The residue was partitioned between ethyl acetate and water adjusting the pH to 7. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous Na2SO4), filtered, and concentrated. Purification by chromatography (0-4% methanol in dichloromethane) afforded the title compound (0.07 g, 71%). %). 1H NMR (300 MHz, DMSO-d6) δ ppm 11.12 (s, 1H) 7.59 (s, 2H) 7.54 (d, J=2.37 Hz, 1H) 7.36-7.50 (m, 4H) 7.17-7.30 (m, 2H) 7.02-7.15 (m, 2H) 6.80 (dd, J=8.31, 1.53 Hz, 2H) 6.74 (s, 1H) 4.48 (s, 2H) 4.46 (s, 2H) 4.12 (s, 3H) 2.93 (s, 3H) 2.91 (s, 3H). MS (ESI+) m/z 741 (M+H)+.

Provenance & Evidence