Potassium Phosphate, Tribasic → HCID 90415835, compound

Participants

Reaction Conditions

Reaction Steps

3,5-dimethylisoxazole-4-boronic acid (0.016 g, 0.112 mmol), the product from Example 91E (0.05 g, 0.093 mmol), tris(dibenzylideneacetone)dipalladium(0) (2.56 mg, 2.79 μmol), 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamante (2.72 mg, 9.30 μmol) and potassium phosphate (0.059 g, 0.279 mmol) were combined and sparged with argon for 15 minutes. Meanwhile a solution of 4:1 dioxane/water (0.8 mL) was sparged with N2 for 15 minutes and transferred by syringe into the reaction vessel under argon. The mixture was heated at 60° C. for 2 hours and partitioned between ethyl acetate and water. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous Na2SO4), treated with 3-mercaptopropyl functionalized silica gel, filtered, and concentrated to afford the title compound (0.052 g, 100%).

Provenance & Evidence