Hydrochloric Acid → HCID 86288168, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 94A (0.052 g, 0.094 mmol) and 4 M hydrogen chloride in dioxane (5 mL, 20.00 mmol) were combined and heated at 70° C. for 4 hours, cooled and concentrated. Purification by chromatography (silica gel, 0-4% methanol in dichloromethane) afforded the title compound (0.042 g, 83%). 1H NMR (300 MHz, DMSO-d6) δ ppm 11.09 (s, 1H) 7.60-7.64 (m, 2H) 7.41-7.53 (m, 1H) 7.21-7.32 (m, 2H) 7.06-7.16 (m, 1H) 6.81 (d, J=8.48 Hz, 1H) 6.57 (s, 1H) 4.51 (s, 2H) 4.13 (s, 3H) 2.92 (s, 3H) 2.35 (s, 3H) 2.18 (s, 3H). MS (ESI+) m/z 540 (M+H)+.

Provenance & Evidence